Open AccessNanoparticulate formulatiom of christmas palm seed (Adonidia merrillii) ethanolic extract containing lactic acid for antidiarrheal therapy
Author(s) -
Mardiyanto Mardiyanto,
Sofia Sandi,
. Herlina,
Ivan Kurniawan
Publication year - 2019
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/1282/1/012084
Subject(s) - zeta potential , dispersity , lactic acid , chemistry , nuclear chemistry , nanoparticle , particle size , traditional medicine , chromatography , materials science , bacteria , organic chemistry , nanotechnology , medicine , biology , genetics
Preparation of Christmas Palm seeds ethanolic extract and lactic acid loaded nanoparticles aims to obtain an antidiarrheal (caused by Escherichia coli ) therapy by using nano herbal. Preparation of the nanoparticles was done by ionic gelation method. There were three formulas (F) which had been evaluated in this study based on the difference amount of Ca(OH) 2 , 12.5 mg for F1, 17.5 mg for F2, and 22.5 mg for F3. All formulas revealed an entrapment efficiency percentage of 75.489 over or less 0.563 (F1); 76.885 over or less 0.046 (F2); and 74.844 over or less 0.724% (F3). The second formula (F2) produced the highest %EE therefore it was distinguished as the optimum formula. The results of nanoparticles characterization of an optimum formula such as average diameter, poly dispersity index (PDI), and zeta potential using particle size analyzer were 1230.1 nm; 0.482; dan 27.5 mV respectively. An in-vivo antidiarrheal evaluation on rats using an optimum formula containing 1 gram of extract showed that nanoparticles possed an equal antidiarrheal effect to intraperitoneal gentamicin sulfate 8 mg/kg body weight with diarrhea inhibitory of 71.539%.