Open AccessFlavonoids from stem bark of akway (Drymis beccariana Gibs) and theirs antimalarial properties
Author(s) -
Tati Herlina,
Tarso Rudiana,
Euis Julaeha,
Apriani Sulu Parubak
Publication year - 2019
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/1280/2/022010
Subject(s) - traditional medicine , bark (sound) , biology , medicine , ecology
Akway (Drimys beccariana , Gibbs ) is a plant endemic to Papua highlands contained in Manokwari . D. beccariana is used for traditional malaria treatment in West Papua. The methanol extract of stem bark of D. beccariana showed antimalarial activity against Plasmodium falciparum parasites, in vitro . Methanol extract of D. beccariana is partitioned between water and n -hexane (1:9), and ethyl acetate. Furthermore, ethyl acetate extract was separated through several combination of chromatography techniques on silica gel, resulting in three known compounds (1-3). The chemical structures of compounds (1-3) were identified based on IR, UV/Vis, 1 H NMR and 13 C NMR, and MS data as 5,3’-dihydroxy-7,4’-dimethoxyflavone (1), 5,7-dihydroxy-4’-methoxyflavone (2), and 5-hydroxy-7,3’,4’-trimethoxyflavone (3). Compounds 1-3 showed strong antiplasmodium against 3D7 strain of P. falciparum with IC 50 values of 0.002, 0.005, and 0.001 micro Molar, respectively. This result indicates that stem bark of D. beccariana is a promising source of antimalarial agents, and merits further investigation.