Open AccessPharmacological and Biological Evaluation of 5,5’[(1,4-Phenelene) bis (1,3,4-thiadiazol-2-amine)]
Author(s) -
Ban M. S. Saeed,
Shaker A. N. Al-Jadaan,
Basil A. Abbas
Publication year - 2019
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/1279/1/012038
Subject(s) - bacillus cereus , staphylococcus aureus , escherichia coli , cereus , amine gas treating , chemistry , bacteria , microbiology and biotechnology , biology , biochemistry , organic chemistry , genetics , gene
The thiadiazole 2-amines compound have been synthesis in this study. The biological activity of the compound was determined at 100, 150, 200 and 250 mg/ml against four types of bacteria i.e. Bacillus cereus , Staphylococcus aureus , Escherichia coli and Slmonella sp. The results of MIC were 2,5,4,5 mg/ml for Bacillus cereus , Staphylococcus aureus , Escherichia coli and Slmonella spp, respectively. Median lethal dose (LD 50 ) and cytotoxic activity were also investigated. The results showed that this compound did not affect the red blood until the concentration reach 30mg/ml or above. The LD 50 for this compound is 0.01994 gm/kg bw.