Open AccessSynthesis of a Novel 4,4’-[1,4-phenylenebis(1,3,4-thiadiazole-5,2-diyl)] bis(azaneylylidene) bis(methaneylylidene) diphenol and Determination of Its pharmacological and antimicrobial Activities
Author(s) -
Ban M. S. Saeed,
Shaker A. N. Al-Jadaan,
Basil A. Abbas
Publication year - 2019
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/1279/1/012037
Subject(s) - bacillus cereus , staphylococcus aureus , antimicrobial , escherichia coli , minimum inhibitory concentration , chemistry , cereus , bacteria , microbiology and biotechnology , biology , biochemistry , genetics , gene
The Cytotoxic activity, median lethal dose (LD 50 ) and the biological activity of new Schiff base compound was determined at 100, 150, 200 and 250 mg/ml against four types of bacteria i.e. Bacillus cereus , Staphylococcus aureus , Escherichia coli and Slmonella sp. and its minimum inhibitory concentration (MIC) was 2,5,4,5 mg/ml for Bacillus cereus , Staphylococcus aureus , Escherichia coli and Slmonella sp. respectively. Median lethal dose (LD 50 ) and cytotoxic activity were also investigated. The results showed that this compound did not affect the red blood until the concentration reach 100mg/ml or above. The LD 50 for the compound is 0.28278 gm/kg bw.