Open AccessMathematical modeling regulatory mechanisms of a viral infection caused by hepatitis D virus with taking into account co-infection and super-infection
Author(s) -
Mahruy Saidalieva,
Mohiniso Hidirova
Publication year - 2019
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/1260/10/102015
Subject(s) - cirrhosis , hepatitis , hepatitis c virus , virology , hepatitis a virus , viral hepatitis , virus , immunology , liver disease , medicine , biology
The purpose of this paper is to develop mathematical and computer models for the regulatory mechanisms of the interconnected activity between liver cells, the hepatitis B virus and hepatitis D virus molecular-genetic systems at hepatitis D infectious process. The paper draws the results made by using methods of quantitative and qualitative analyse of functional-differential equations. The paper concludes that the developed model which has oscillatory mode, chaotic regime and destructive changes that can be identified by chronic hepatitis D with intermittent crisis, with severe hepatitis D and liver cirrhosis. The paper provides a new mathematical and computer models which are able to describe hepatitis D regulatory mechanisms and to diagnose the infectious process course and predict the outcome of disease.