Open AccessSeluang (Rasbora agrotyenia) Fish Oil Increases Vitamin D in Autoimmune Patients (Systemic Lupus Erythematosus)
Author(s) -
Ester G. Penserga,
Radiyati Umi Partan,
Rachmat Hidayat,
Nurwan Saputra,
Hari Prapto,
Febri Rahmayani
Publication year - 2019
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/1246/1/012036
Subject(s) - medicine , vitamin d and neurology , placebo , proinflammatory cytokine , osteoporosis , lupus erythematosus , gastroenterology , immune system , immunology , physiology , inflammation , pathology , antibody , alternative medicine
Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease which usually affects multiple organ systems. Its patients are prone to hypovitaminosis D along with its complications such as osteoporosis. The improvement of vitamin D status in SLE patients is associated with better immune modulation, proinflammatory cytokine suppression, calcium absorption improvement, as well as better severity and lower osteoclastogenesis. This double-blind, randomised clinical trial was conducted in the Allergology-Immunology Polyclinic in the Internal Medicine Department of Mohammad Hoesin General Hospital, Palembang, Indonesia, over the period April 2017 – February 2018. Samples were given either seluang ( Rasbora agrotyenia ) fish oil or placebo for 12 weeks. On the start and the end of the study, vitamin D levels were examined. 32 patients, all female, were divided evenly into the two groups. On the end of the study, the seluang oil group had significant vitamin D increase compared to placebo (p = 0.000). We concluded that the administration of seluang fish oil was able to increase vitamin D levels in SLE patients.