Open AccessAssociation of vascular endothelial growth factor gene +405 C>G and -460 C>T polymorphism with diabetic foot ulcer in Indonesia
Author(s) -
Kemas Muhammad Dahlan,
Dedy Pratama,
Akhmadu Muradi,
Dwi Anita Suryandari,
Luluk Yunaini,
Setyawati Boediningsih
Publication year - 2019
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/1246/1/012008
Subject(s) - vascular endothelial growth factor , genotype , medicine , allele , gastroenterology , angiogenesis , endocrinology , vegf receptors , gene , biology , genetics
Background, the greatest risk factor for Diabetic foot ulcer (DFU) is neuropathy. Vascular endothelial growth factor (VEGF) gene is a gene encodes a protein vascular endothelial growth factor (VEGF), which has a function of angiogenesis and neurogenesis. VEGF plays a role in neuropathy, angiopathy and wound healing in DFU. Methods: Case-control study, case is types 2 DM with DFU and control is type 2 DM without DFU, Polymerase Chain Reaction-Restriction Fragment length polymorphism was done to find genotype polymorphism of VEGF gene. Results: Genotype GG VEGF + 405C> G does not have a significant association with DFU in DM patients (GG + CG / CC; OR; 0.52, 95% CI; 0.15 to 1.73 p; 0.289). G allele is proposed as a protective factor in DFU (OR; 0.86, 95% CI 0.57 to 1.28, and p; 0.456). Genotype TT from VEGF gene -460 C> T; have no significant association with DFU (TT + CT / CC; OR; 0.97, 95% CI; 0.41 to 2.26 and p; 0.942). T allele is predicted as protective factor in DFU (OR; 0.90, 95% CI; 0.59 to 1.37 and p; 0,641). Conclusion: G alleles and T alleles are predicted as a protective factor in DM patients associated with DFU.