Open AccessRelationship of estrogen beta (ERβ) receptor genes polymorphism with epithelial ovarian cancer
Author(s) -
Ria Andreinieelel,
Sri Nita,
Irsan Saleh
Publication year - 2019
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/1246/1/012005
Subject(s) - ovarian cancer , estrogen receptor , genotype , estrogen receptor beta , estrogen receptor alpha , biology , medicine , estrogen , endocrinology , allele , genotyping , cancer , cancer research , breast cancer , gene , genetics
Ovarian cancer is the leading cause of death among all uterine diseases. Ovarian cancer is affected by exogenous and endogenous estrogen factors. Beta estrogen receptors are predominant estrogen receptors in the normal ovary. Polymorphisms in the beta estrogen receptor gene (ERβ) can affect the risk of epithelial ovarian cancer through regulation of cell proliferation and apoptosis. The purpose of this study was to determine the relationship of beta estrogen receptor gene polymorphism (ERβ) with epithelial ovarian cancer incidence. Method: a case-control study, there were 60 samples. A single nucleotide polymorphism in the beta estrogen receptor (RsaI/rs1256049) is selected. Genotyping using PCR-RFLP. Data were analyzed by Chi-square, considered significant if the p-value is less than 0.05. Results: there is no significant difference in the characteristics of respondents. Genotypic frequency in the case group was 56.7% GG, 43.3% GA/AA and control group was 23.2% GG, 76.7% GA/AA. The frequency of alleles in the case group was 78.3% G, 21.7% A and control which was 50% G, 50% A allele. ERβ polymorphism is associated with epithelial ovarian cancer ( p 0.018). Allele A in RsaI was associated with epithelial ovarian cancer ( p 0.002). Polymorphism of the beta estrogen receptor gene associated with epithelial ovarian cancer.