Open AccessResearch on protein folding of cannabinoid receptor type II based on HP model
Author(s) -
Zhengfu Li,
Fan Liang,
Hongyan Zhuang,
Jiaojiao Li,
Cunhua Li
Publication year - 2019
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/1237/5/052003
Subject(s) - cannabinoid receptor type 2 , folding (dsp implementation) , genetic algorithm , mechanism (biology) , cannabinoid receptor , computer science , protein folding , cannabinoid , mathematical optimization , receptor , algorithm , biological system , mathematics , chemistry , biology , physics , biochemistry , engineering , quantum mechanics , electrical engineering , agonist
Cannabinoid receptor type II (CB2 for short) is a subtype of cannabinoid receptor. At present, the three-dimensional conformation of CB2 protein has not been determined. In this paper, a protein folding method of CB2 based on HP model and genetic algorithm are proposed, which can help to study the folding mechanism and pharmacological properties of CB2. By using the backtracking mechanism, the genetic algorithm, which can help to solve this optimization problem, can help to avoid local optimization. The folding results obtained by the algorithm are analysed and compared. The experimental results demonstrate that the CB2 conformation obtained by genetic algorithm has a lower energy value, which is a good basis for further research on CB2 folding mechanism.