Open AccessSynthesis, Identification and Studying Biological Activity of Some Heterocyclic Derivatives from 3, 5-Dinitrosalicylic Acid
Author(s) -
R Kais,
Shaimaa Adnan
Publication year - 2019
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/1234/1/012091
Subject(s) - chemistry , phthalic anhydride , thioglycolic acid , tetrazole , sodium azide , organic chemistry , combinatorial chemistry , catalysis
The study deals with synthesizing new thiadiazole compound (2-(5-amino-1,3,4-thiadiaz0l-2-yl)-4,6-dinitrophenol)(1) by reaction of 3,5-dinitrosalicylic acid with thiosemicarbazide in Phosphoric chloride, then it is (1) reacted with 2-Bromobenzaldehydeto getting Schiff base (2-(5-((2-bromobenzylidene) amino)-1,3,4-thiadiaz0l-2-yl)-4,6-dinitrophenol)(2). T0he compound (2) will reacted with (chloroacetylchloride, thioglycolic acid, glycine, sodium azide, phthalic anhydride) to give (β-lactam, thiazolidine, imidazolidine, tetrazole, oxazepine) derivatives respectively. The new synthesized compounds have been identified by their melting points, 1 H-NMR, 13 C-NMR and FT-IR spectra. Then the biological activity studied for all the synthesized derivatives toward two type of bacteria.