Open AccessRoadmap on plasticity and epigenetics in cancer
Author(s) -
Jasmine Foo,
David Basanta,
Russell C. Rockne,
Carly Strelez,
Curran Shah,
Kimya Ghaffarian,
Shan M. Mumenthaler,
Kelly Mitchell,
Justin D. Lathia,
David Frankhouser,
Sergio Branciamore,
YaHuei Kuo,
Guido Marcucci,
Robert Vander Velde,
Andriy Marusyk,
Sui Hang,
Kishore Hari,
Mohit Kumar Jolly,
Haralampos Hatzikirou,
Kamrine E. Poels,
Mary E. Spilker,
Blerta Shtylla,
Mark Robertson-Tessi,
Alexander R.A. Anderson
Publication year - 2022
Publication title -
physical biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.137
H-Index - 68
eISSN - 1478-3975
pISSN - 1478-3967
DOI - 10.1088/1478-3975/ac4ee2
Subject(s) - epigenetics , plasticity , biology , phenotypic plasticity , computational biology , evolutionary biology , cognitive science , computer science , genetics , psychology , physics , gene , thermodynamics
The role of plasticity and epigenetics in shaping cancer evolution and response to therapy has taken center stage with recent technological advances including single cell sequencing. This roadmap article is focused on state-of-the-art mathematical and experimental approaches to interrogate plasticity in cancer, and addresses the following themes and questions: is there a formal overarching framework that encompasses both non-genetic plasticity and mutation-driven somatic evolution? How do we measure and model the role of the microenvironment in influencing/controlling non-genetic plasticity? How can we experimentally study non-genetic plasticity? Which mathematical techniques are required or best suited? What are the clinical and practical applications and implications of these concepts?