Open Access3 tera-basepairs as a fundamental limit for robust DNA replication
Author(s) -
Mohammed Al Mamun,
Luca Albergante,
J. Julian Blow,
T. J. Newman
Publication year - 2020
Publication title -
physical biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.137
H-Index - 68
eISSN - 1478-3975
pISSN - 1478-3967
DOI - 10.1088/1478-3975/ab8c2f
Subject(s) - dna replication , biology , genome , dna , computational biology , gene duplication , genetics , robustness (evolution) , evolutionary biology , gene
In order to maintain functional robustness and species integrity, organisms must ensure high fidelity of the genome duplication process. This is particularly true during early development, where cell division is often occurring both rapidly and coherently. By studying the extreme limits of suppressing DNA replication failure due to double fork stall errors, we uncover a fundamental constant that describes a trade-off between genome size and architectural complexity of the developing organism. This constant has the approximate value N U ≈ 3 × 10 12 basepairs, and depends only on two highly conserved molecular properties of DNA biology. We show that our theory is successful in interpreting a diverse range of data across the Eukaryota.