Open AccessImaging of 99mTc-DMSA and 18F-FDG in humans using a Si/CdTe Compton camera
Author(s) -
Takashi Nakano,
Makoto Sakai,
Kohei Torikai,
Yoshiyuki Suzuki,
Shin’ichiro Takeda,
Shinei Noda,
Mitsutaka Yamaguchi,
Yuto Nagao,
Mikiko Kikuchi,
Hirokazu Odaka,
Tomihiro Kamiya,
Naoki Kawachi,
Shin Watanabe,
Kazuo Arakawa,
Tadayuki Takahashi
Publication year - 2020
Publication title -
physics in medicine and biology/physics in medicine and biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.312
H-Index - 191
eISSN - 1361-6560
pISSN - 0031-9155
DOI - 10.1088/1361-6560/ab33d8
Subject(s) - nuclear medicine , positron emission tomography , single photon emission computed tomography , physics , cadmium telluride photovoltaics , emission computed tomography , medical imaging , materials science , optics , medicine , radiology , optoelectronics
The Compton camera can simultaneously acquire images of multiple isotopes injected in a body; therefore, it has the potential to introduce a new subfield in the field of biomedical imaging applications. The objective of this study is to assess the ability of a prototype semiconductor-based silicon/cadmium telluride (Si/CdTe) Compton camera to simultaneously image the distributions of technetium ( 99m Tc)-dimercaptosuccinic acid (DMSA) (141 keV emission) and 18 F-fluorodeoxyglucose (FDG) (511 keV emission) injected into a human volunteer. 99m Tc-DMSA and 18 F-FDG were injected intravenously into a 25-year-old male volunteer. The distributions of 99m Tc-DMSA and 18 F-FDG were simultaneously made visible by setting a specified energy window for each radioisotope. The images of these radiopharmaceuticals acquired using the prototype Compton camera were superimposed onto computed tomography images for reference. The reconstructed image showed that 99m Tc-DMSA had accumulated in both kidneys, which is consistent with the well-known diagnostic distribution determined by clinical imaging via single-photon emission computed tomography. In the 18 F-FDG image, there is broad distribution around the liver and kidneys, which was expected based on routine clinical positron emission tomography imaging. The current study demonstrated for the first time that the Si/CdTe Compton camera was capable of simultaneously imaging the distributions of two radiopharmaceuticals, 99m Tc-DMSA and 18 F-FDG, in a human body. These results suggest that the Si/CdTe Compton camera has the potential to become a novel modality for nuclear medical diagnoses enabling multi-probe simultaneous tracking.