Open AccessA customized multispectral needle probe combined with a virtual photometric setup for in vivo detection of Lewis lung carcinoma in an animal model
Author(s) -
Frank Braun,
Robert Schalk,
Marcel Nachtmann,
Andreas Hien,
Ronald Frank,
Thomas Beuermann,
FrankJürgen Methner,
Bettina Kränzlin,
Matthias Rädle,
Norbert Gretz
Publication year - 2019
Publication title -
measurement science and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.48
H-Index - 136
eISSN - 1361-6501
pISSN - 0957-0233
DOI - 10.1088/1361-6501/ab24a1
Subject(s) - multispectral image , in vivo , lewis lung carcinoma , materials science , fluorescence , biomedical engineering , adipose tissue , near infrared spectroscopy , optics , pathology , computer science , chemistry , biology , cancer , computer vision , physics , medicine , biochemistry , microbiology and biotechnology , metastasis , genetics
Optical systems applied for tissue analysis are primarily based on single spectroscopic techniques. This paper however presents a multispectral backscattering sensor designed for in vivo application by a specially formed probe tip which allows side by side monitoring of ultraviolet, visible, near-infrared and fluorescence spectra. The practical applicability of the measurement system was demonstrated in vitro (muscle and adipose tissue) and in vivo in an animal model (mouse). By comparing associated measuring changes in biochemical, physical-morphological and colorimetric values this procedure allows a differentiation between healthy, marginal and malignant tissue.