Open AccessLeak-free integrated microfluidic channel fabrication for surface plasmon resonance applications
Author(s) -
Mohamed-Taieb Bakouche,
Sivaramakrishnan Ganesan,
David Guérin,
D. Hourlier,
Mohamed Bouazaoui,
Jean-Pierre Vilcot,
Sophie Maricot
Publication year - 2020
Publication title -
journal of micromechanics and microengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.494
H-Index - 132
eISSN - 1361-6439
pISSN - 0960-1317
DOI - 10.1088/1361-6439/abb991
Subject(s) - polydimethylsiloxane , surface plasmon resonance , microfluidics , materials science , fabrication , monolayer , nanotechnology , fluidics , contact angle , optoelectronics , composite material , nanoparticle , medicine , alternative medicine , pathology , aerospace engineering , engineering
In this paper, we describe a novel fabrication method of a microfluidic integrated surface plasmon resonance (SPR) gold chip based on a (3-mercaptopropyl) trimethoxy silane (MPTMS) self-assembled monolayer. This monolayer was formed at the surface of a microfluidic chip made of polydimethylsiloxane (PDMS). Its presence was confirmed by contact angle and Fourier transform infrared spectroscopy measurements on the modified PDMS surface. A basic, but nevertheless appropriate, 4-channel microfluidic system was made on PDMS and reported on a gold SPR sensor. Sealing tests were carried-out by injecting continuous flows of solutions under gradient pressure up to 1.8 bar. Bonding strength of chemical and corona binding were measured and compared. The test of the integrated microfluidic SPR sensor on an SPR bench validated its functionality and proved as well that no leakage is observed between the different microfluidic channels.