Open AccessControl of neuronal network organization by chemical surface functionalization of multi-walled carbon nanotube arrays
Author(s) -
Jie Liu,
Florence Appaix,
Olivier Bibari,
Gilles Marchand,
AlimLouis Benabid,
Fabien Sauter-Starace,
Michel De Waard
Publication year - 2011
Publication title -
nanotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.926
H-Index - 203
eISSN - 1361-6528
pISSN - 0957-4484
DOI - 10.1088/0957-4484/22/19/195101
Subject(s) - surface modification , carbon nanotube , materials science , nanotechnology , neurite , interfacing , nanotube , chemical modification , chemical engineering , computer science , polymer chemistry , chemistry , biochemistry , computer hardware , engineering , in vitro
International audienceCarbon nanotube substrates are promising candidates for biological applications and devices. Interfacing of these carbon nanotubes with neurons can be controlled by chemical modifications. In this study, we investigated how chemical surface functionalization of multi-walled carbon nanotube arrays (MWNT-A) influences neuronal adhesion and network organization. Functionalization of MWNT-A dramatically modifies the length of neurite fascicles, cluster inter-connection success rate, and the percentage of neurites that escape from the clusters. We propose that chemical functionalization represents a method of choice for developing applications in which neuronal patterning on MWNT-A substrates is required