Open AccessThe Emerging Role of Metabolomics in the Development of Biomarkers for Pulmonary Hypertension and other Cardiovascular Diseases (2013 Grover Conference Series)
Author(s) -
Lewis Gregory D.
Publication year - 2014
Publication title -
pulmonary circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.791
H-Index - 40
ISSN - 2045-8940
DOI - 10.1086/677369
Subject(s) - medicine , metabolomics , pulmonary hypertension , metabolite profiling , disease , metabolite , bioinformatics , computational biology , intensive care medicine , biology
The functional and prognostic significance of pulmonary hypertension (PH) is well established, yet our understanding of circulating peptides and metabolites that might mark or contribute to various forms of PH remains limited. Metabolites are the end result of all the regulatory complexity present in a cell, tissue, or organism and therefore serve as the most proximal reporters of the body's response to a disease process or drug therapy. This review presents the rationale, methodology, and preliminary findings from studies that apply comprehensive metabolite profiling to gain knowledge of new circulating markers of PH.