Open AccessMortality among Patients with Methicillin-ResistantStaphylococcus aureusUSA300 versus Non-USA300 Invasive Infections: A Meta-Analysis
Author(s) -
Rajeshwari Nair,
Eric M. Ammann,
Matthew A. Rysavy,
Marin L. Schweizer
Publication year - 2014
Publication title -
infection control and hospital epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.243
H-Index - 138
eISSN - 1559-6834
pISSN - 0899-823X
DOI - 10.1086/674385
Subject(s) - medicine , methicillin resistant staphylococcus aureus , odds ratio , meta analysis , confidence interval , staphylococcal infections , staphylococcus aureus , observational study , epidemiology , mortality rate , biology , bacteria , genetics
Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has been found to be epidemiologically and microbiologically distinct from healthcare-associated MRSA. Most CA-MRSA infections are not invasive; however, fatal outcomes have been reported among healthy people with CA-MRSA invasive infections. Epidemiological studies have attributed a major burden of CA-MRSA infections in the United States to the predominant clone USA300. We investigated the association between USA300 invasive infections and mortality by conducting a systematic review and meta-analysis of studies that reported mortality rates associated with USA300 strains.