Iatrogenic Transmission of Human T Cell Lymphotropic Virus Type 1 and Hepatitis C Virus through Parenteral Treatment and Chemoprophylaxis of Sleeping Sickness in Colonial Equatorial Africa | Zendy

Jacques Pépin | Zendy; AnnieClaude Labbé | Zendy; Fleurie MamadouYaya | Zendy; Pascal Mbélesso | Zendy; Sylvestre Mbadingaï | Zendy; Sylvie Deslandes | Zendy; MarieClaude Locas | Zendy; Éric Frost | Zendy

Open Access

Iatrogenic Transmission of Human T Cell Lymphotropic Virus Type 1 and Hepatitis C Virus through Parenteral Treatment and Chemoprophylaxis of Sleeping Sickness in Colonial Equatorial Africa

Author(s) -

Jacques Pépin,

AnnieClaude Labbé,

Fleurie MamadouYaya,

Pascal Mbélesso,

Sylvestre Mbadingaï,

Sylvie Deslandes,

MarieClaude Locas,

Éric Frost

Publication year - 2010

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/656232

Subject(s) - medicine , chemoprophylaxis , transmission (telecommunications) , population , virology , immunology , hepatitis c virus , pentamidine , odds ratio , virus , environmental health , pneumonia , electrical engineering , engineering

The simultaneous emergence of human immunodeficiency virus (HIV)-1 group M and HIV-2 into human populations, circa 1921-1940, is attributed to urbanization and changes in sexual behavior. We hypothesized that the initial dissemination of HIV-1, before sexual transmission predominated, was facilitated by the administration, via reusable syringes and needles, of parenteral drugs against tropical diseases. As proxies for highly lethal HIV-1, we investigated risk factors for hepatitis C virus (HCV) and human T cell lymphotropic virus 1 (HTLV-1) infections, blood-borne viruses compatible with prolonged survival, in an area known in 1936-1950 as the most virulent focus of African trypanosomiasis.

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