C1q‐ and Collectin‐Dependent Phagocytosis of Apoptotic Host Cells by the Intestinal ProtozoanEntamoeba histolytica | Zendy

José E. Teixeira | Zendy; Bradley T. Heron | Zendy; Christopher D. Huston | Zendy

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C1q‐ and Collectin‐Dependent Phagocytosis of Apoptotic Host Cells by the Intestinal ProtozoanEntamoeba histolytica

Author(s) -

José E. Teixeira,

Bradley T. Heron,

Christopher D. Huston

Publication year - 2008

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/591628

Subject(s) - collectin , phagocytosis , opsonin , biology , entamoeba histolytica , efferocytosis , microbiology and biotechnology , macrophage , innate immune system , immunology , immune system , biochemistry , in vitro

Entamoeba histolytica, the cause of invasive amebiasis, phagocytoses apoptotic host cells during tissue invasion. In mammals, collectin family members (e.g., mannose-binding lectin [MBL]) and the structurally related protein C1q bind to apoptotic cells and stimulate macrophage phagocytosis via a conserved collagenous tail domain. The collectins also bind to bacteria, the usual source of nutrients for E. histolytica.

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