Emergence of Carbapenem-Resistant Klebsiella Species Possessing the Class A Carbapenem-Hydrolyzing KPC-2 and Inhibitor-Resistant TEM-30 -Lactamases in New York City | Zendy

Patricia A. Bradford | Zendy; Simona Bratu | Zendy; Carl Urban | Zendy; Maria Visalli | Zendy; N Mariano | Zendy; David Landman | Zendy; James J. Rahal | Zendy; Steven E. Brooks | Zendy; S. Cebular | Zendy; John Quale | Zendy

Open Access

Emergence of Carbapenem-Resistant Klebsiella Species Possessing the Class A Carbapenem-Hydrolyzing KPC-2 and Inhibitor-Resistant TEM-30 -Lactamases in New York City

Author(s) -

Patricia A. Bradford,

Simona Bratu,

Carl Urban,

Maria Visalli,

N Mariano,

David Landman,

James J. Rahal,

Steven E. Brooks,

S. Cebular,

John Quale

Publication year - 2004

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/421495

Subject(s) - klebsiella pneumoniae , microbiology and biotechnology , carbapenem , beta lactamase , klebsiella , enterobacteriaceae , beta lactamase inhibitors , biology , medicine , virology , antibiotics , escherichia coli , genetics , gene

Nineteen isolates of carbapenem-resistant Klebsiella species were recovered from 7 hospitals in New York City. Most K. pneumoniae belonged to a single ribotype. Nucleotide sequencing identified KPC-2, a carbapenem-hydrolyzing beta -lactamase. In 3 strains, TEM-30, an inhibitor-resistant beta -lactamase, was detected. Carbapenem-resistant Klebsiella species possessing KPC-2 are endemic in New York City. This study documents the identification of an inhibitor-resistant TEM beta -lactamase in the United States.

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