Open AccessNeuronal metabotropic glutamate receptor 8 protects against neurodegeneration in CNS inflammation
Author(s) -
Marcel S Woo,
Friederike Ufer,
Nicola Rothammer,
Giovanni Di Liberto,
Lars Binkle,
Undine Haferkamp,
Jana K. Sonner,
Jan Broder Engler,
Sönke Hornig,
Simone Bauer,
Ingrid Wagner,
Kristóf Égervári,
Jacob Raber,
Robert M. Duvoisin,
Ole Pleß,
Doron Merkler,
Manuel A. Friese
Publication year - 2021
Publication title -
the journal of experimental medicine/the journal of experimental medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 8.483
H-Index - 448
eISSN - 1540-9538
pISSN - 0022-1007
DOI - 10.1084/jem.20201290
Subject(s) - excitotoxicity , neuroprotection , glutamate receptor , metabotropic glutamate receptor 8 , neurodegeneration , metabotropic glutamate receptor , neuroscience , metabotropic glutamate receptor 5 , metabotropic receptor , biology , receptor , pharmacology , medicine , disease , biochemistry
Systematic analysis of the neuronal receptor interactome in multiple sclerosis brains reveals the metabotropic glutamate receptor 8 as a disbalanced hub. Its activation constitutes a novel treatment strategy to enhance neuronal resilience by inhibiting pathological calcium overload in inflammation-induced neurodegeneration.