Single-cell analyses identify circulating anti-tumor CD8 T cells and markers for their enrichment | Zendy

Kristen E. Pauken | Zendy; Osmaan Shahid | Zendy; Kaitlyn A. Lagattuta | Zendy; Kelly Mahuron | Zendy; Jacob M. Luber | Zendy; Margaret M. Lowe | Zendy; Linglin Huang | Zendy; Conor P. Delaney | Zendy; Jaclyn M. Long | Zendy; Megan E. Fung | Zendy; Kathleen Newcomer | Zendy; Katy K. Tsai | Zendy; Melissa Chow | Zendy; Samantha Guinn | Zendy; Juhi R. Kuchroo | Zendy; Kelly P. Burke | Zendy; Jason M. Schenkel | Zendy; Michael D. Rosenblum | Zendy; Adil Daud | Zendy; Arlene H. Sharpe | Zendy; Meromit Singer | Zendy

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Single-cell analyses identify circulating anti-tumor CD8 T cells and markers for their enrichment

Author(s) -

Kristen E. Pauken,

Osmaan Shahid,

Kaitlyn A. Lagattuta,

Kelly Mahuron,

Jacob M. Luber,

Margaret M. Lowe,

Linglin Huang,

Conor P. Delaney,

Jaclyn M. Long,

Megan E. Fung,

Kathleen Newcomer,

Katy K. Tsai,

Melissa Chow,

Samantha Guinn,

Juhi R. Kuchroo,

Kelly P. Burke,

Jason M. Schenkel,

Michael D. Rosenblum,

Adil Daud,

Arlene H. Sharpe,

Meromit Singer

Publication year - 2021

Publication title -

the journal of experimental medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 8.483

H-Index - 448

eISSN - 1540-9538

pISSN - 0022-1007

DOI - 10.1084/jem.20200920

Subject(s) - cytotoxic t cell , cell , cd8 , circulating tumor cell , microbiology and biotechnology , biology , chemistry , computational biology , immunology , antigen , genetics , cancer , in vitro , metastasis

Using single-cell RNA sequencing and TCR sequencing, Pauken et al. detect CD8 + T cell clones shared between blood and tumor in mice or melanoma patients, characterize matching clones in blood and tumor, and identify potential biomarkers for their isolation in blood.

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