Open AccessCombined deletion of Bap1, Nf2, and Cdkn2ab causes rapid onset of malignant mesothelioma in mice
Author(s) -
Jitendra Badhai,
Gaurav Kumar Pandey,
JiYing Song,
Oscar Krijgsman,
Rajith Bhaskaran,
G. Chandrasekaran,
Min Chul Kwon,
Lorenzo Bombardelli,
Kim Monkhorst,
Cristoforo Grasso,
John Zevenhoven,
Jan van der Vliet,
Miranda Cozijnsen,
Paul Krimpenfort,
Daniel S. Peeper,
Maarten van Lohuizen,
Anton Berns
Publication year - 2020
Publication title -
the journal of experimental medicine/the journal of experimental medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 8.483
H-Index - 448
eISSN - 1540-9538
pISSN - 0022-1007
DOI - 10.1084/jem.20191257
Subject(s) - mesothelioma , cancer research , bap1 , phenotype , pathogenesis , biology , immunotherapy , suppressor , medicine , gene , melanoma , immunology , pathology , immune system , genetics
Badhai et al. describe a mouse model of mesothelioma with combined deletion of Bap1 , Nf2 , and Cdkn2ab that shows rapid onset and recapitulates human mesothelioma including its response to the standard treatment. This autochthonous model is well suited for testing cancer immunotherapies.