Open AccessPathogenic T cell cytokines in multiple sclerosis
Author(s) -
Catriona A. Wagner,
Pamela J. Roqué,
Joan Goverman
Publication year - 2019
Publication title -
the journal of experimental medicine/the journal of experimental medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 8.483
H-Index - 448
eISSN - 1540-9538
pISSN - 0022-1007
DOI - 10.1084/jem.20190460
Subject(s) - multiple sclerosis , immunology , disease , pathogenesis , cytokine , medicine , etiology , autoimmunity , experimental autoimmune encephalomyelitis , autoimmune disease , demyelinating disease , immune system , pathology , antibody
Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system that is believed to have an autoimmune etiology. As MS is the most common nontraumatic disease that causes disability in young adults, extensive research has been devoted to identifying therapeutic targets. In this review, we discuss the current understanding derived from studies of patients with MS and animal models of how specific cytokines produced by autoreactive CD4 T cells contribute to the pathogenesis of MS. Defining the roles of these cytokines will lead to a better understanding of the potential of cytokine-based therapies for patients with MS.