3D FIB-SEM reconstruction of microtubule–organelle interaction in whole primary mouse β cells | Zendy

Andreas Müller | Zendy; Deborah Schmidt | Zendy; C. Shan Xu | Zendy; Song Pang | Zendy; Joyson Verner D’Costa | Zendy; Susanne Kretschmar | Zendy; Carla Münster | Zendy; Thomas Kurth | Zendy; Florian Jug | Zendy; Martin Weigert | Zendy; Harald F. Hess | Zendy; Michele Solimena | Zendy

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3D FIB-SEM reconstruction of microtubule–organelle interaction in whole primary mouse β cells

Author(s) -

Andreas Müller,

Deborah Schmidt,

C. Shan Xu,

Song Pang,

Joyson Verner D’Costa,

Susanne Kretschmar,

Carla Münster,

Thomas Kurth,

Florian Jug,

Martin Weigert,

Harald F. Hess,

Michele Solimena

Publication year - 2020

Publication title -

the journal of cell biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.414

H-Index - 380

eISSN - 1540-8140

pISSN - 0021-9525

DOI - 10.1083/jcb.202010039

Subject(s) - microtubule , microbiology and biotechnology , golgi apparatus , centriole , secretory vesicle , biology , secretion , organelle , vesicle , exocytosis , biochemistry , membrane , endoplasmic reticulum

Müller et al. provide the first full 3D reconstructions of microtubule networks in a mammalian cell, the islet β cell. Microtubules are mostly disconnected from centrioles and endomembranes, while associated with cortical insulin granules, highlighting their importance for regulated secretion.

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