Open AccessRhoGAP19D inhibits Cdc42 laterally to control epithelial cell shape and prevent invasion
Author(s) -
Weronika Fic,
Rebecca Bastock,
Francesco Raimondi,
Erinn Los,
Yoshiko Inoue,
Jennifer L. Gallop,
Robert B. Russell,
Daniel St Johnston
Publication year - 2021
Publication title -
the journal of cell biology/the journal of cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.414
H-Index - 380
eISSN - 1540-8140
pISSN - 0021-9525
DOI - 10.1083/jcb.202009116
Subject(s) - cdc42 , biology , microbiology and biotechnology , cell polarity , cadherin , epithelium , adherens junction , apical membrane , myosin , exocyst , polarity (international relations) , motility , epithelial polarity , gtpase , secretion , cell , biochemistry , exocytosis , genetics
Fic et al. identify Drosophila RhoGAP19D as a novel epithelial polarity factor that excludes active Cdc42 from the lateral domain. Loss of RhoGAP19D causes apical domain expansion, lateral contractility, and invasion of adjacent tissues, a phenotype resembling that of precancerous breast lesions.