RhoGAP19D inhibits Cdc42 laterally to control epithelial cell shape and prevent invasion | Zendy

Weronika Fic | Zendy; Rebecca Bastock | Zendy; Francesco Raimondi | Zendy; Erinn Los | Zendy; Yoshiko Inoue | Zendy; Jennifer L. Gallop | Zendy; Robert B. Russell | Zendy; Daniel St Johnston | Zendy

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RhoGAP19D inhibits Cdc42 laterally to control epithelial cell shape and prevent invasion

Author(s) -

Weronika Fic,

Rebecca Bastock,

Francesco Raimondi,

Erinn Los,

Yoshiko Inoue,

Jennifer L. Gallop,

Robert B. Russell,

Daniel St Johnston

Publication year - 2021

Publication title -

the journal of cell biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.414

H-Index - 380

eISSN - 1540-8140

pISSN - 0021-9525

DOI - 10.1083/jcb.202009116

Subject(s) - cdc42 , biology , microbiology and biotechnology , cell polarity , cadherin , epithelium , adherens junction , apical membrane , myosin , exocyst , polarity (international relations) , motility , epithelial polarity , gtpase , secretion , cell , biochemistry , exocytosis , genetics

Fic et al. identify Drosophila RhoGAP19D as a novel epithelial polarity factor that excludes active Cdc42 from the lateral domain. Loss of RhoGAP19D causes apical domain expansion, lateral contractility, and invasion of adjacent tissues, a phenotype resembling that of precancerous breast lesions.

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