Induction of spontaneous human neocentromere formation and long-term maturation | Zendy

Marina Murillo-Pineda | Zendy; Luis P. Valente | Zendy; Marie Dumont | Zendy; João F. Mata | Zendy; Daniele Fachinetti | Zendy; Lars E.T. Jansen | Zendy

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Induction of spontaneous human neocentromere formation and long-term maturation

Author(s) -

Marina Murillo-Pineda,

Luis P. Valente,

Marie Dumont,

João F. Mata,

Daniele Fachinetti,

Lars E.T. Jansen

Publication year - 2021

Publication title -

the journal of cell biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.414

H-Index - 380

eISSN - 1540-8140

pISSN - 0021-9525

DOI - 10.1083/jcb.202007210

Subject(s) - biology , centromere , chromatin , genetics , histone h3 , histone , kinetochore , microbiology and biotechnology , chromosome , gene

Murillo-Pineda et al. report a chromosome engineering system for human neocentromere formation and characterize the first experimentally generated human neocentromere. Neocentromere formation promotes local H3K9me3 eviction and cohesin and RNA polymerase II recruitment. Long-term culture results in gradual maturation of the inner centromere.

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