The deubiquitylase USP9X controls ribosomal stalling | Zendy

Anne Clancy | Zendy; Claire Heride | Zendy; Adán Pinto-Fernández | Zendy; Hannah Elcocks | Zendy; Andreas Kallinos | Zendy; Katherine J. Kayser-Bricker | Zendy; Weiping Wang | Zendy; Victoria Smith | Zendy; Simon Davis | Zendy; Shawn P. Fessler | Zendy; Crystal McKin | Zendy; Marie Katz | Zendy; Tim Hammonds | Zendy; Neil P. Jones | Zendy; Jonathan C. O’Connell | Zendy; Bruce Follows | Zendy; Steven Mischke | Zendy; Justin A. Caravella | Zendy; Stephanos Ioannidis | Zendy; Christopher J. Dinsmore | Zendy; Sunkyu Kim | Zendy; Axel Behrens | Zendy; David Komander | Zendy; Benedikt M. Kessler | Zendy; Sylvie Urbé | Zendy; Michael J. Clague | Zendy

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The deubiquitylase USP9X controls ribosomal stalling

Author(s) -

Anne Clancy,

Claire Heride,

Adán Pinto-Fernández,

Hannah Elcocks,

Andreas Kallinos,

Katherine J. Kayser-Bricker,

Weiping Wang,

Victoria Smith,

Simon Davis,

Shawn P. Fessler,

Crystal McKin,

Marie Katz,

Tim Hammonds,

Neil P. Jones,

Jonathan C. O’Connell,

Bruce Follows,

Steven Mischke,

Justin A. Caravella,

Stephanos Ioannidis,

Christopher J. Dinsmore,

Sunkyu Kim,

Axel Behrens,

David Komander,

Benedikt M. Kessler,

Sylvie Urbé,

Michael J. Clague

Publication year - 2021

Publication title -

the journal of cell biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.414

H-Index - 380

eISSN - 1540-8140

pISSN - 0021-9525

DOI - 10.1083/jcb.202004211

Subject(s) - ribosome , ubiquitin , ribosomal rna , ribosomal protein , microbiology and biotechnology , translation (biology) , chemistry , biology , computational biology , biochemistry , messenger rna , rna , gene

Clancy et al. develop a specific chemical inhibitor of USP9X and characterize its effects upon the cellular proteome. This analysis reveals a central role in the regulation of ribosomal stalling through control of critical E3 ligases.

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