Lymphatic exosomes promote dendritic cell migration along guidance cues | Zendy

Markus Brown | Zendy; Louise A. Johnson | Zendy; Dario A. Leone | Zendy; Peter Májek | Zendy; Kari Vaahtomeri | Zendy; Daniel Senfter | Zendy; Nora Bukosza | Zendy; Helga Schachner | Zendy; Gabriele Asfour | Zendy; Brigitte Langer | Zendy; Robert Hauschild | Zendy; Katja Parapatics | Zendy; YoungKwon Hong | Zendy; Keiryn L. Bennett | Zendy; Renate Kain | Zendy; Michael Detmar | Zendy; Michael Sixt | Zendy; David G. Jackson | Zendy; Dontscho Kerjaschki | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Lymphatic exosomes promote dendritic cell migration along guidance cues

Author(s) -

Markus Brown,

Louise A. Johnson,

Dario A. Leone,

Peter Májek,

Kari Vaahtomeri,

Daniel Senfter,

Nora Bukosza,

Helga Schachner,

Gabriele Asfour,

Brigitte Langer,

Robert Hauschild,

Katja Parapatics,

YoungKwon Hong,

Keiryn L. Bennett,

Renate Kain,

Michael Detmar,

Michael Sixt,

David G. Jackson,

Dontscho Kerjaschki

Publication year - 2018

Publication title -

the journal of cell biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.414

H-Index - 380

eISSN - 1540-8140

pISSN - 0021-9525

DOI - 10.1083/jcb.201612051

Subject(s) - microvesicles , lymphatic system , microbiology and biotechnology , dendritic cell , biology , immunology , microrna , immune system , genetics , gene

Lymphatic endothelial cells (LECs) release extracellular chemokines to guide the migration of dendritic cells. In this study, we report that LECs also release basolateral exosome-rich endothelial vesicles (EEVs) that are secreted in greater numbers in the presence of inflammatory cytokines and accumulate in the perivascular stroma of small lymphatic vessels in human chronic inflammatory diseases. Proteomic analyses of EEV fractions identified >1,700 cargo proteins and revealed a dominant motility-promoting protein signature. In vitro and ex vivo EEV fractions augmented cellular protrusion formation in a CX3CL1/fractalkine-dependent fashion and enhanced the directional migratory response of human dendritic cells along guidance cues. We conclude that perilymphatic LEC exosomes enhance exploratory behavior and thus promote directional migration of CX3CR1-expressing cells in complex tissue environments.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research