Open AccessIRSp53 keeps ECM signaling up to Par
Author(s) -
Ben Short
Publication year - 2011
Publication title -
the journal of cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.414
H-Index - 380
eISSN - 1540-8140
pISSN - 0021-9525
DOI - 10.1083/jcb.1923iti3
Subject(s) - biology , microbiology and biotechnology , laminin , polarity (international relations) , actin , cell polarity , phosphorylation , basal (medicine) , cell , biochemistry , extracellular matrix , endocrinology , insulin
![Figure][1] Compared with wild-type cells (left), cells lacking IRSp53 (right) form cysts with multiple, misoriented lumens (magenta) and fail to deposit laminin (green) evenly around their basal surface.Par1b controls cell polarity by phosphorylating an actin-regulatory protein to inhibit
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