Open AccessAutophagy balances a Highwire act in synapse development
Author(s) -
Ben Short
Publication year - 2009
Publication title -
the journal of cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.414
H-Index - 380
eISSN - 1540-8140
pISSN - 0021-9525
DOI - 10.1083/jcb.1871iti2
Subject(s) - biology , autophagy , synapse , microbiology and biotechnology , drosophila (subgenus) , proteasome , neuroscience , genetics , gene , apoptosis
Autophagy plays a surprisingly constructive role in Drosophila synapse development, counteracting a proteasome-mediated degradation pathway, say [Shen and Ganetzky.][1]![Figure][2] NMJs are smaller in flies lacking Atg1 (left) and overgrown in flies overexpressing the protein (right).
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