Open AccessHow ER stress gives cells the CHOP
Author(s) -
Ben Short
Publication year - 2009
Publication title -
the journal of cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.414
H-Index - 380
eISSN - 1540-8140
pISSN - 0021-9525
DOI - 10.1083/jcb.1866iti1
Subject(s) - endoplasmic reticulum , unfolded protein response , biology , chop , microbiology and biotechnology , apoptosis , translation (biology) , biochemistry , gene , messenger rna
Li et al. explain how prolonged stress sparks the endoplasmic reticulum (ER) to release its calcium stores, inducing cells to undergo apoptosis in several aging-related diseases.Stressful conditions cause misfolded proteins to accumulate in the ER. Cells try to recover by slowing down translation
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