Open AccessYoung proteins cut down in their prime
Author(s) -
Mitch Leslie
Publication year - 2008
Publication title -
the journal of cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.414
H-Index - 380
eISSN - 1540-8140
pISSN - 0021-9525
DOI - 10.1083/jcb.1824iti4
Subject(s) - biology , prime (order theory) , microbiology and biotechnology , biochemistry , combinatorics , mathematics
“Last hired, first fired” is the rule when businesses are laying off workers. As [Medicherla and Goldberg][1] show, cells follow a similar strategy when weeding out damaged proteins, eliminating the freshly manufactured molecules.Defective proteins, such as those induced by heat or reactive
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