Open AccessAbundance of ITAM prevents autoimmunity
Author(s) -
Richard Robinson
Publication year - 2008
Publication title -
the journal of cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.414
H-Index - 380
eISSN - 1540-8140
pISSN - 0021-9525
DOI - 10.1083/jcb.1815rr2
Subject(s) - biology , autoimmunity , abundance (ecology) , computational biology , antibody , immunology , ecology
For T cell receptors, more activation motifs means less autoimmunity, say Jeff Holst, Dario Vignali (St. Jude's Children's Research Hospital, Memphis, TN), and colleagues.The T cell receptor's four CD3 subunits contain a total of 10 tyrosine-based activation motifs (ITAMs). These motifs dock with
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