Open AccessHuntington's disease protein extends its reach
Author(s) -
Mitch Leslie
Publication year - 2008
Publication title -
the journal of cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.414
H-Index - 380
eISSN - 1540-8140
pISSN - 0021-9525
DOI - 10.1083/jcb.1815iti1
Subject(s) - huntingtin , biology , cytoplasm , mutant , nucleus , huntingtin protein , huntington's disease , microbiology and biotechnology , nuclear protein , disease , genetics , gene , transcription factor , pathology , medicine
![Graphic][1] Cytoplasmic clumps of mutant huntingtin (arrows, top) are smaller in cells that produce an internal antibody (bottom). The mutant protein that causes Huntington's disease doesn't just wreak havoc inside the nucleus. It also makes trouble in the cytoplasm, as [Wang et
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