Premium
Copper‐Dependent Oxidative Stress and Neurodegeneration
Author(s) -
Rotilio G.,
Carr` M. T.,
Rossi L.,
Ciriolo M. R.
Publication year - 2000
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/713803724
Subject(s) - neurodegeneration , amyotrophic lateral sclerosis , oxidative stress , copper metabolism , disease , neuroscience , menkes disease , copper , biology , medicine , chemistry , biochemistry , pathology , organic chemistry
Abstract Copper is an essential trace element, but its redox reactivity leads to risks of damage to cell and tissues. These are well exemplified by several forms of neurodegenerative diseases, either arising as inherited disorders of copper metabolism, such as Menkes' and Wilson's disease, or as conformational diseases such as Alzheimer's disease and prion diseases. This review will cover some aspects of the involvement of copper‐mediated oxidative stress in degenerative processes in the central nervous system, with special focus on the familial form of amyotrophic lateral sclerosis (FALS). Furthermore, a possible role of copper reactivity in inducing critical steps in the apoptotic pathways leading to neurodegeneration is envisaged.