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Oxidized Lipoproteins in Blood Plasma: Possible Marker of Atherosclerosis Progression
Author(s) -
Moriel Patricia,
Okawabata Fabio S.,
Abdalla Dulcineia S. P.
Publication year - 1999
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/713803534
Subject(s) - chemistry , very low density lipoprotein , cholesterol , phospholipid , medicine , endocrinology , plasma lipoprotein , lipoprotein , blood plasma , intermediate density lipoprotein , biochemistry , biology , membrane
Oxidized lipoproteins and antioxidants were detected during the course of hypercholesterolemia development in cholesterol‐fed rabbits. Lipid peroxides in blood plasma and very‐low‐, low‐, and high‐density lipoproteins (beta‐VLDL, LDL, and HDL) were increased during the course of hypercholesterolemia. The content of phospholipid peroxides increased in beta‐VLDL and LDL in parallel to that of cholesterol, whereas the amount of alpha‐tocopherol was decreased either in lipoproteins or blood plasma. Ascorbate and urate concentrations were also decreased. Lipid peroxides were positively correlated with volume and area of atherosclerotic lesions, suggesting a relation between the concentrations of lipid peroxides in blood plasma and the progression of atheromatous lesions.