Premium
The Role of Iron in Parkinson Disease and 1‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine Toxicity
Author(s) -
Yantiri Ferda,
Andersen Julie K.
Publication year - 1999
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/713803493
Subject(s) - substantia nigra , pars compacta , parkinson's disease , dopaminergic , oxidative stress , degeneration (medical) , neuroscience , toxicity , disease , dopamine , medicine , biology , pathology
Parkinson disease (PD) involves the specific degeneration of dopaminergic neurons ofthe pars compacta ofthe substantia nigra. Although the cause of the degeneration of nigrostrial dopaminergic neurons in PD is unknown, there is significant evidence to suggest that oxidative stress may be involved in this process. This review specifically examines the current status of evidence suggesting iron may contribute to oxidative damage associated with PD.