Open AccessExtracellular vesicles circulating in young organisms promote healthy longevity
Author(s) -
Prattichizzo Francesco,
Giuliani Angelica,
Sabbatinelli Jacopo,
Mensà Emanuela,
De Nigris Valeria,
La Sala Lucia,
Candia Paola,
Olivieri Fabiola,
Ceriello Antonio
Publication year - 2019
Publication title -
journal of extracellular vesicles
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.94
H-Index - 68
ISSN - 2001-3078
DOI - 10.1080/20013078.2019.1656044
Subject(s) - extracellular vesicles , parabiosis , longevity , microbiology and biotechnology , vesicle , ageing , biology , extracellular , extracellular vesicle , microvesicles , immunology , biochemistry , genetics , microrna , gene , membrane
Parabiosis experiments in mice demonstrated that a young environment could partially rejuvenate multiple tissues of old organisms. However, the circulating mediators responsible of such effect have been elusive so far. Novel results suggest that extracellular vesicles isolated from plasma of young mice increase lifespan in old mice. Here we integrate these findings in a larger framework, advancing the hypothesis that circulating vesicles may mediate the beneficial effect of a young milieu on ageing.