Open AccessSummary of the ISEV workshop on extracellular vesicles as disease biomarkers, held in Birmingham, UK, during December 2017
Author(s) -
Clayton Aled,
Buschmann Dominik,
Byrd J. Brian,
Carter David R. F.,
Cheng Lesley,
Compton Carolyn,
Daaboul George,
Devitt Andrew,
FalconPerez Juan Manuel,
Gardiner Chris,
Gustafson Dakota,
Harrison Paul,
Helmbrecht Clemens,
Hendrix An,
Hill Andrew,
Hoffman Andrew,
Jones Jennifer C.,
Kalluri Raghu,
Kang Ji Yoon,
Kirchner Benedikt,
Lässer Cecilia,
Lawson Charlotte,
Lenassi Metka,
Levin Carina,
Llorente Alicia,
MartensUzunova Elena S.,
Möller Andreas,
Musante Luca,
Ochiya Takahiro,
Pink Ryan C,
Tahara Hidetoshi,
Wauben Marca H. M.,
Webber Jason P.,
Welsh Joshua A.,
Witwer Kenneth W.,
Yin Hang,
Nieuwland Rienk
Publication year - 2018
Publication title -
journal of extracellular vesicles
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.94
H-Index - 68
ISSN - 2001-3078
DOI - 10.1080/20013078.2018.1473707
Subject(s) - extracellular vesicles , credentialing , extracellular vesicle , certification , medicine , isolation (microbiology) , benchmarking , computer science , medical education , bioinformatics , microvesicles , political science , biology , business , microrna , biochemistry , marketing , gene , law , microbiology and biotechnology
This report summarises the presentations and activities of the ISEV Workshop on extracellular vesicle biomarkers held in Birmingham, UK during December 2017. Among the key messages was broad agreement about the importance of biospecimen science. Much greater attention needs to be paid towards the provenance of collected samples. The workshop also highlighted clear gaps in our knowledge about pre‐analytical factors that alter extracellular vesicles (EVs). The future utility of certified standards for credentialing of instruments and software, to analyse EV and for tracking the influence of isolation steps on the structure and content of EVs were also discussed. Several example studies were presented, demonstrating the potential utility for EVs in disease diagnosis, prognosis, longitudinal serial testing and stratification of patients. The conclusion of the workshop was that more effort focused on pre‐analytical issues and benchmarking of isolation methods is needed to strengthen collaborations and advance more effective biomarkers.