Open AccessMesozeaxanthin protects the liver and reduces cardio-metabolic risk factors in an insulin resistant rodent model
Author(s) -
Kazım Şahin,
Cemal Orhan,
Fatih Akdemir,
Mehmet Tuzcu,
Nurhan Şahin,
İsmet Yılmaz,
Shakir Ali,
Jayant V. Deshpandé,
Vijaya Juturu
Publication year - 2017
Publication title -
food and nutrition research/food and nutrition research. supplement
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 37
eISSN - 1654-6628
pISSN - 1654-661X
DOI - 10.1080/16546628.2017.1353360
Subject(s) - medicine , endocrinology , insulin resistance , adiponectin , irs1 , antioxidant , tumor necrosis factor alpha , metabolic syndrome , insulin , insulin receptor , hepatocyte nuclear factors , hepatocyte , peroxisome proliferator activated receptor , diabetes mellitus , fatty liver , chemistry , receptor , biochemistry , transcription factor , disease , in vitro , gene
Background: Mesozeaxanthin (MZ) is a macular carotenoid which has been reported to have a number of pharmacological properties, including the antioxidant, and anticarcinogenic property, and has been stated to decrease the hepatocyte lipid content. Objective: In this study, we investigated the effect of MZ on cardio-metabolic health risk (CMHR) and its probable mechanisms of action in rats fed a high-fat diet (HFD). Design: Rats were randomly divided into four groups consisting of (i) Control, (ii) MZ, (iii) HFD, and (iv) HFD+MZ. Results: MZ treatment increased the antioxidant enzyme activities and helped improve the liver function. The treatment alleviated CMHR and decreased the level of nuclear factor kappa B (NF-κB p65) and tumor necrosis factor-alpha (TNF-α). The levels of hepatic peroxisome proliferator-activated receptor gamma (PPAR-γ), phosphorylated insulin receptor substrate 1 (p-IRS-1), β,β-carotene 9’,10’-oxygenase 2 (BCO2) and nuclear factor erythroid 2-related factor 2 (Nrf2), which decrease in HFD rats, were found to be significantly higher in MZ supplemented animals. Conclusion: MZ has antioxidant and anti-inflammatory properties and can is reported in this study toprotect against fatty liver and cardio-metabolic syndrome, possibly through regulation of PPAR-γ, IRS-1, Nrf2 and NF-κB proteins, in an insulin-resistant rodent model.