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Expression of the Na ‐H exchanger isoform‐1 and cyclooxygenases in human placentas: Their implications in preeclampsia
Author(s) -
Khan Islam,
AlYatama M.,
Nandakumaran M.
Publication year - 1999
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549900201783
Subject(s) - preeclampsia , cyclooxygenase , sodium–hydrogen antiporter , gene isoform , placenta , endocrinology , medicine , pathogenesis , chemistry , prostaglandin , homeostasis , prostaglandin e , andrology , biology , pregnancy , sodium , biochemistry , fetus , enzyme , gene , genetics , organic chemistry
The sodium hydrogen exchanger isoform, NHE‐1 plays an important role in electrolyte and water homeostasis. These functions are compromised in pregnancies complicated with preeclampsia. At present it is not known whether NHE‐1 expression is altered during preeclampsia. In the present study the placental level of NHE‐1 protein was measured using immunoblotting. Since prostaglandins regulate the secretory and absorptive functions, the levels of prostaglandin E‐2 as well as the expression of cyclooxygenase‐1 and ‐2 were also estimated. The amount of NHE‐1 protein and cyclooxygenase‐2 was reduced in preeclamptic placentas, whereas the level of cyclooxygenase‐1 remained unaltered. In contrast, prostaglandin E‐2 concentration was higher in preeclampsia. Suppression of NHE‐1 might render the placenta with impaired uptake of water and electrolytes and therefore may be involved in the pathogenesis of preeclampsia. While prostaglandin E‐2 may play a role in preeclampsia, these findings discount the induction of cyclooxygenase‐genes for this increase.