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Citrate carrier and lipogenic enzyme activities in lead intrate‐induced proliferative and apoptotic phase in rat liver
Author(s) -
Dini Luciana,
Giudetti Anna Maria,
Ruzittu Mariateresa,
Gi Gabriele V.,
Zara Vincenzo
Publication year - 1999
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549900201653
Subject(s) - enzyme , chemistry , in vivo , medicine , cytosol , endocrinology , hepatocyte , acetyl coa carboxylase , biochemistry , biology , pyruvate carboxylase , in vitro , microbiology and biotechnology
Abstract After in vivo administration of lead nitrate, functional changes of the mitochondrial tricarboxylate carrier and of the cytosolic lipogenic enzymes acetyl‐CoA carboxylase and fatty acid synthetase have been detected in rat liver. The rate of citrate transport was greatly reduced in rats during both the proliferative phase (3 days after the lead nitrate administration) and the involutive phase (5 days after the metal injection), which follows hepatic hyperplasia and corresponds to the peak of hepatocyte apoptosis. In both phases, a decrease of the lipogenic enzyme activities has been detected. In treated animals, an alteration of mitochondrial lipid composition has also been found. The modified lipid microenvironment could be responsible for the decreased carrier activity which, in turn, may account for the reduced activities of the lipogenic enzymes.