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Expression of two dead box gene (DDX1 amd DDX6) is independent of that of MYCN in human neuroblastoma cell lines
Author(s) -
Akiyama Kiyotaka,
Akao Yukihiro,
Yokoyama Masahiro,
Nakagawa Yoshihito,
Noguchi Tohru,
Yagi Kunio,
Nishi Yoshisuke
Publication year - 1999
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549900201603
Subject(s) - neuroblastoma , dead box , biology , gene , gene expression , messenger rna , gene duplication , cell culture , cancer research , genetics , rna , helicase
To examine whether two DEAD box genes, DDX1 and DDX6, would have some roles in the progression of tumors, we investigated the correlation of the expression of these genes with that of MYCN in neuroblastomas either with or without MYCN amplification. The mRNA of MYCN was observed only in the cell lines with amplification of MYCN. The mRNAs of DDX1 and DDX6 were found in all the cell lines examined, but the correlation between the mRNA levels of DDX1 or DDX6 and MYCN was poor. These findings suggest that the expression of neither DEAD box gene is correlated with the gene expression of MYCN.