Orthophosphate is a non‐essential activator of Vigna radiata flavokinase | Zendy

DasPanja Kaberi | Zendy; Jonnalagadda Vidya S. | Zendy; Jonnalagadda Sobhanaditya | Zendy

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Orthophosphate is a non‐essential activator of Vigna radiata flavokinase

Author(s) -

DasPanja Kaberi,

Jonnalagadda Vidya S.,

Jonnalagadda Sobhanaditya

Publication year - 1999

Publication title -

iubmb life

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.132

H-Index - 113

eISSN - 1521-6551

pISSN - 1521-6543

DOI - 10.1080/15216549900201583

Subject(s) - vigna , activator (genetics) , pi , radiata , phosphate , chemistry , phosphorylation , biochemistry , stereochemistry , biophysics , biology , botany , receptor

The ATP‐dependent phosphorylation of riboflavin to FMN by flavokinase from Vigna radiata was activated by orthophosphate (Pi) in a concentration dependent manner. Pi affected both the Km and Vmax, indicating that it is a non‐essential, mixed type activator. The extent of activation by Pi was dependent on the cation (Mg2+ or Zn2+). Activation by other anions could be correlated to similarity to Pi in molecular size and structure. These observations suggest the presence of a binding site(s) for a phosphate‐like anion on flavokinase.

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