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Evaluation of kidney and liver subacute toxicity induced by bezalip ‐ pravastatin. Lopid antihyperlipidaemic compounds in rats
Author(s) -
Pispirigos K.,
Simopoulos K.,
Kouskoukis K.,
Kounis N.,
Avramopoulos A.
Publication year - 1999
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549900201553
Subject(s) - toxicity , pravastatin , uric acid , creatinine , chemistry , alkaline phosphatase , blood urea nitrogen , cholesterol , kidney , pharmacology , endocrinology , medicine , reductase , enzyme , biochemistry , biology
Renal and hepatic subacute toxicity induced by the antihyperlipidaemic drugs: Bezalip ‐ Pravastatin and Lopid was investigated in rats using serum biochemical parameters. Toxicological evaluation was performed in serum samples following the administration of the therapeutic dose regimens of the compounds that were previously shown to be effective in inhibition of 3‐hydroxy‐methylgiutaryl coenzyme A (HMG CoA) reductase, the enzyme controlling the rate‐limiting step in the synthesis of cholesterol, and acyl‐ CoA cholesterol acyl transferase (ACAT) which converts intracellnlar free cholesterol to cholesterol ester. Renal and hepatic subacute toxicity was evaluated by measuring enzyme activity or concentrations of: alanine aminotransferace, alkaline phosphatase, asparate aminotransferase, γ‐glutamyltransferase, glucose, potassium, sodium, blood urea nitrogen, uric acid and creatinine. The use of the above serum biochemical parameters indicated that the overall toxicity impact of antihyperlipidaemic drugs was Bezalip = Pravastatin < Lopid. We have found that the Pravastatin ‐in contrast to the above antihyperlipidaemic drags‐ only transiently affects the biochemical parameters associated with toxicity, but, it affects some of the biochemical parameters associated with hepatic and renal toxicity, up to a significantly lower extent than the antihyperlipidaemic drags.