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Protein folding as a nonlinear nonequilibrium thermodynamic process
Author(s) -
Popov E. M.
Publication year - 1999
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549900201473
Subject(s) - non equilibrium thermodynamics , protein folding , nonlinear system , constructive , statistical physics , folding (dsp implementation) , downhill folding , structure formation , sequence (biology) , entropy (arrow of time) , thermodynamics , phi value analysis , physics , process (computing) , chemistry , computer science , engineering , biochemistry , quantum mechanics , galaxy , electrical engineering , nuclear magnetic resonance , operating system
Biofurcational theory of protein folding is developed describing the process of formation of protein native structure as a sequence of non‐equilibrium irreversible fluctuations, specific for a particular protein. The model gives explaination to all characteristic features of the folding process: stochastic mechanism, short time and precision of proteins self‐assembling. A constructiwe role of entropy in the formation of a highly ordered structure out of disorder is discussed. A numerical method of a priori calculations of polypeptide structures basing on principles of bifractional folding model is presented.