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Influence of a melatonin implant on the free radical load in avian thydroid and its relation with thyroid hormonogenesis
Author(s) -
Prakash Prem,
Laloraya Malini,
Pradeep Kumar G.
Publication year - 1998
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549800204822
Subject(s) - melatonin , medicine , thyroid , endocrinology , triiodothyronine , superoxide dismutase , hormone , lipid peroxidation , chemistry , pineal gland , biology , oxidative stress
The primary aim of this study was to evaluate the effect of melatonin on the oxyradical load in avian thyroid. The superoxide free radicals have been spin trapped by EPR spectroscopy in the thyroid gland of Indian rock pigeon Columba livia following melatonin implantation for two weeks. Melatonin implantation resulted in augmentation in the levels of superoxde radical in the thyroid gland of pigeons with a concomitant decrease in the levels of the total superoxide dismutase activity. This was also associated with increased lipid peroxidation. Melatonin implantation caused a significant increase in plasma levels of glucose. Plasma levels of thyroxine (T4) and triiodothyronine (T3) were lower in the melatonin‐treated pigeons. However, the T3/T4 ratio was higher following melatonin implantation. Since iodination of tyrosine is an H2O2‐dependent phenomenon, the inhibition in the activity of SOD could lead to impaired thyroid hormone synthesis.