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Increased metabolism of peroxynitrite‐modified [125I] β‐VLDL by monocytes from hypercholesterolemic rabbits
Author(s) -
Silva E.L. da,
Abdalla D. S. P.
Publication year - 1998
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549800203852
Subject(s) - peroxynitrite , very low density lipoprotein , chemistry , metabolism , biochemistry , monocyte , endocrinology , medicine , lipoprotein , cholesterol , biology , superoxide , enzyme
The metabolism (uptake and degradation) of peroxynitrite‐modified β‐VLDL and native β‐VLDL labeled with [125I]iodine was studied in monocytes isolated from peripheral blood of hypercholesterolemic (HC) and normolipidemic rabbits (NC). The peroxynitrite‐modified β‐VLDL uptake and degradation was up to 2‐fold higher in monocytes from HC rabbits than monocytes from NC rabbits. In addition, monocytes from HC rabbits took up and degraded significantly more peroxynitrite‐modified β‐VLDL than native β‐VLDL. In contrast, monocytes from NC rabbits took up both lipoproteins in a similar rate and degraded more native β‐VLDL than peroxynitrite‐modified β‐VLDL. Our results suggest that hypercholesterolemia can affect monocyte metabolism enhancing foam cell formation by increasing the influx of peroxynitrite‐modified β‐VLDL.